Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.

Inclusion Criteria:

• ICU patient with severe sepsis
• Treated with aminoglycosides

Exclusion Criteria:

• Renal replacement therapy
• Allergy to aminoglycosides
• Confirmed and/or suspected to have myasthenia
• ICU-acquired neuromuscular disorder
• Under guardianship
• Prisoners
• The patient has already participated in the present protocol