Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Inclusion Criteria:

• physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

Exclusion Criteria:

• physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI