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Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults
The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cherry concentrate | Active Comparator | 8 weeks supplementation with montmorency cherry concentrate |
|
| Placebo concentrate | Placebo Comparator | 8 weeks supplementation with placebo isoenergetic cherry concentrate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cherry concentrate | Dietary Supplement |
| ||
| Placebo concentrate |
| Measure | Description | Time Frame |
|---|---|---|
| Brain perfusion | Arterial spin labelling using MRI, measure will be reported as ml/min | Change from baseline to 8 weeks supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function | Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported | Change from baseline to 8 weeks supplementation |
| Brain activation (fMRI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joanna L Bowtell, PhD | University of Exeter | Principal Investigator |
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| Dietary Supplement |
|
fMRI using a hippocampal biased task
| Change from baseline to 8 weeks supplementation |
| Plasma nitrite concentration | Plasma sample analysed via chemiluminescence technique | Change from baseline to 8 weeks supplementation |