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| Name | Class |
|---|---|
| Cherry Marketing Institute | OTHER |
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A randomized, double blind, counterbalanced, placebo controlled independent groups design to determine the effects of 3 month supplementation with tart cherry concentrate on indices of cardiometabolic health, exercise capacity and cognitive function. Following screening and recruitment, participants are familiarised with the testing equipment and procedures after which they will be randomly assigned to receive either Montmorency tart cherry concentrate (MC) or an isocaloric placebo (PLA), stratified by gender. The study is comprised of two experimental visits and outcome variables are assessed at baseline (before supplementation) and at 3 months (follow up; after supplementation).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Montmorency tart cherry concentrate | Active Comparator | Participants will consume 30 ml of Montmorency tart cherry concentrate (MC) concentrate (King Orchard farms, USA) twice daily, once in the morning and again in the evening. According to the manufacturer each 30 ml dose of MC is estimated to be equivalent to approximately 90 whole cherries (equating to ~180 cherries per day). |
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| Isocaloric cherry flavoured placebo | Placebo Comparator | The PLA is prepared by mixing by mixing unsweetened black cherry flavoured Kool-Aid (Kraft Foods, United States), dextrose, fructose with water to best match the calorie content of the MC concentrate. Additional lemon juice, for tartness, and artificial food colouring is added so the final product had a similar visual properties to the active comparator. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Montmorency tart cherry concentrate | Dietary Supplement | Based on previous analysis done by our laboratory each 60 ml of Montmorency tart cherry concentrate contains approximately 73.5 mg of anthocyanins (cyanidin-3-glucoside equivalents) and 178.8 mg of total phenolics (mean gallic acid equivalents) |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) | Change from baseline at 3 months |
| Arterial Stiffness | Pulse wave velocity (m/s) | Change from baseline at 3 months |
| Arterial Stiffness | Augmentation index (%) | Change from baseline at 3 months |
| Endothelial function | Flow mediated dilation (% change) | Change from baseline at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Indices of metabolic health | glucose (mmol/L) triglycerides (mmol/L) LDL cholesterol (mmol/L) HDL cholesterol (mmol/L) | Change from baseline at 3 months |
| Cognitive function | Computerized cognitive function assessment percentage accuracy (%) |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Fat mass (g) Lean mass (g) | Change from baseline at 3 months |
| Body composition | Fat percentage (%) | Change from baseline at 3 months |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | NE18ST | United Kingdom |
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The treatment drink (tart cherry concentrate) and placebo are matched for colour and packed in identical plastic containers. The assigned beverages are packed and given to the participants by an independent researcher not involved in the study.
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| Placebo | Dietary Supplement | Placebo beverage matched for calorie content and visual properties of the cherry concentrate |
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| Change from baseline at 3 months |
| Cognitive function | Computerized cognitive function assessment reaction time (m/s) | Change from baseline at 3 months |
| Cerebral Blood flow | Oxygenated heamoglobin (Oxyhb) | Change from baseline at 3 months |
| Cerebral Blood flow | Deoxygenated heamoglobin (deoxyhb) | Change from baseline at 3 months |
| Exercise Capacity | Estimated aerobic exercise capacity (VO2max) measured by a submaximal cycling test | Change from baseline at 3 months |
| Body composition | Android/gynoid ratio | Change from baseline at 3 months |