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Prospective observational study.
A varicocele is defined as a dilatation of the veins in the plexus pampiniformis in the testicles. Varicoceles are a diagnostic dilemma and a therapeutic challenge. Most of the boys with a varicocele don't show any symptoms, but approximately 15-20% experience some sort of infertility later during their life. There still isn't any consensus on when treating the patient is the right choice. Reliable scientific research about parameters able to predict the later stages of the boy with a varicocele is therefore needed. The purpose of this study is to how testicular growth could predict the outcome of boys with a varicocele.
During this study, testicular growth in boys with and without a left-sided varicocele will be examined in different schools using ultrasound to measure the testicular volumes, the PRF and the TAI to be able to collect sufficient data with the purpose to be able to predict whether testicular growth is a significant predictor on the progression of a varicocele.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Boys without varicocele | Boys thoroughly examined but without diagnose of varicocele |
| |
| Boys with a varicocoele | Boys with a diagnosed varicocele of any stage possible. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound | Diagnostic Test | We use ultrasound to measure the PRF and the testicular volumes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in testicular volumes in adolescents boys | Scrotal ultrasound is performed to assess testicular dimensions after which testicular volume is calculated. Multiple measurements are performed over a time period of 3 years. | 3 years |
| Chang in haemodynamic parameters in adolescent boys with a varicocele | Scrotal doppler ultrasound is performed and the peak retrograde flow is determined. Multiple measurements are performed over a time period of 3 years. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Semen analysis in varicoele patients | Routine standard semen analysis as well as DNA fragmentation testing. | After liquefaction (30-35 minutes after ejaculation) |
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Inclusion Criteria:
1. Boys aged 11-16 years without any evidence of a current or past pathology influencing testicular growth
Exclusion Criteria:
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The study population consists of adolescent boys with or without a varicocele being between the age 11 and 16 years old when enlisting in the study. Recruitment took place at the Antwerp University Hospital and through medical checkups in secondary schools in Antwerp and West-Flanders.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gunter De Win, MD PhD FEABU | Contact | 3 821 55 86 | +32 | gunter.dewin@uza.be |
| Donald Vaganée, Dr. | Contact | 3 821 30 47 | +32 | donald.vaganee@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gunter De Win, MD PhD FEABU | University Hospital, Antwerp | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Antwerp University Hospital | Recruiting | Edegem | Antwerp | 2650 | Belgium |
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| ID | Term |
|---|---|
| D014646 | Varicocele |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |