Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 1R21DA041580-01A1 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Institute on Drug Abuse (NIDA) | NIH |
Not provided
Not provided
Not provided
Not provided
The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Synthetic Psychoactive Cannabinoid Users | Other | Synthetic Psychoactive Cannabinoid dependent subjects who are frequent spice/K2 users will receive the radiotracer [11-C]OMAR. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [11-C]OMAR | Other | The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Positron Emission Tomography (PET Imaging) | CB1R availability using [11-C]OMAR PET imaging Change in CB1R availability (e.g. volume distribution). | Change in CB1R availability from baseline throughout one test day |
| Measure | Description | Time Frame |
|---|---|---|
| CogState Battery | 2. Changes in Cognition during withdrawal using a computerized battery Changes in cognitive functions such as attention, memory, motor functioning, and processing speed. | Change in CB1R availability from baseline throughout one test day |
| Electroencephalogram |
Not provided
Inclusion:
Exclusion:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Deepak C D'Souza, M.D. | Yale University | Principal Investigator |
| Mohini Ranganathan, M.D. | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Connecticut Mental Health Center | New Haven | Connecticut | 06519 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
3. Changes in brain rhythms measured by Electroencephalography Changes in electroencephalographic (EEG) brain rhythms related to information processing. |
| Change in CB1R availability from baseline throughout one test day |