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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DA040698-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis Dependent Subjects | Subjects who are frequent cannabis users |
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| Healthy Controls | Subjects with no current cannabis use |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [11-C]OMAR | Drug | The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan. |
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| Measure | Description | Time Frame |
|---|---|---|
| CB1R availability using [11-C]OMAR PET imaging | Change in CB1R availability (e.g. volume distribution). | Change in CB1R availability from baseline to 48 hours and 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Cognition during withdrawal using a computerized battery | Changes in cognitive functions such as attention, memory, motor functioning, and processing speed. | Change in CB1R availability from baseline to 48 hours and 28 days |
| Changes in brain rhythms measured by Electroencephalography |
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Inclusion Criteria: Cannabis Dependent Subjects
Inclusion Criteria for Healthy Controls
Exclusion Criteria:
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Research subjects can be both cannabis-using or non-cannabis using males and females between the ages of 18-65.
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| Name | Affiliation | Role |
|---|---|---|
| Mohini Ranganathan, MD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Conneticut Mental Health Center | New Haven | Connecticut | 06519 | United States |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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When specimens and information are stored, researchers are careful to try to protect your identity from discovery by others. Samples and information will receive a unique code. Other researchers will only receive coded samples and information, and will not be able to link the code to subjects. Strict security safeguards are in place to reduce the chance of misuse or unplanned release of information.
Changes in electroencephalographic (EEG) brain rhythms related to information processing. |
| Change in CB1R availability from baseline to 48 hours and 28 days |