The Neural Correlates of Cannabis Use

The Neural Correlates of Cannabis Use

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.

Inclusion Criteria: Cannabis Dependent Subjects

• Current cannabis consumption
• Willing to abstain from cannabis use for four weeks

Inclusion Criteria for Healthy Controls

• No current cannabis consumption

Exclusion Criteria:

• MRI metal exclusions and claustrophobia
• Education completed is less than 12 years