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| Name | Class |
|---|---|
| German Research Foundation | OTHER |
| University Hospital, Bonn | OTHER |
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The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis Dependence | Cannabis dependent individuals according to DSM 4 criteria, aged 18-40 years |
| |
| Healthy | Healthy controls, socio-demographically matched |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence | Activity patterns in core regions of the emotion processing & addiction-related brain networks (e.g. striatal regions, insular cortex, prefrontal cortex) will be assessed after 28-days of abstinence. Alterations will be determined by comparison with matched non-drug using controls | one timepoint = fMRI assessment after 28 day abstinence period |
| Measure | Description | Time Frame |
|---|---|---|
| Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence | Self-reported ratings of pleasantness & rewarding value during soft-pleasant touch. | one timepoint = during fMRI assessment after 28 day abstinence period |
| Relapse interview assessed with Timeline-Followback Method |
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Inclusion Criteria:
Exclusion Criteria:
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Cannabis dependent individuals
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bonn / Department of Psychiatry | Bonn | North Rhine-Westphalia | 53111 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29197984 | Derived | Zimmermann K, Yao S, Heinz M, Zhou F, Dau W, Banger M, Weber B, Hurlemann R, Becker B. Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence. Psychopharmacology (Berl). 2018 Mar;235(3):849-859. doi: 10.1007/s00213-017-4803-6. Epub 2017 Dec 2. |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| D016739 | Behavior, Addictive |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D003192 | Compulsive Behavior |
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Association between fMRI neural correlates and drug use during follow up period as predictor of relapse |
| one timepoint = 24 months post-fMRI-session |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |