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The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery
MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnancy group | Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34) |
| |
| Postpartum group | Postpartum group included women, who were evaluated 6 months after giving birth |
| |
| Non-pregnant group | Women who were systemically healthy and non-pregnant. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saliva collection | Other |
| ||
| GCF collection |
| Measure | Description | Time Frame |
|---|---|---|
| Changing MMP-8 levels | Salivary and GCF level measured by IFMA | 6 months |
| Changing MMP-9 levels | Salivary and GCF level measured by ELISA | 6 months |
| Changing TIMP-1 levels | Salivary and GCF level measured by ELISA | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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All women were systemically healthy
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| Other |
|
| D009057 |
| Stomatognathic Diseases |