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Attention deficit hyperactivity disorder (ADHD) patients have some problem with sustained attention. The dorsal anterior cingulate cortex (dACC) plays a key role for attention control. It has been found that the dACC has strong functional connectivity with ipsilateral motor area and parietal gyrus. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of sustained attention, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and parietal gyrus, and combining rTMS to activate the dACC.
Healthy subject is recruiting in this project. High rTMS will be performed. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real rTMS (motor area) | Experimental | Real rTMS targeting motor area for 30 min |
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| Real rTMS (parietal gyrus) | Experimental | Real rTMS targeting parietal gyrus for 30 min |
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| Real rTMS (both brain area) | Experimental | Real rTMS targeting motor area and parietal gyrus for 15 min, separately |
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| Sham rTMS | Sham Comparator | Sham rTMS targeting motor area and parietal gyrus for 15 min, separately |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rTMS | Device | The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train). |
|
| Measure | Description | Time Frame |
|---|---|---|
| degree of enhanced neuro-activity associated with target-specific treatment | amplitude of low frequency fluctuation | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yu-Feng Zang, M.D. | Hangzhou Normal University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hangzhou Normal University,Center for Cognition and Brain Disorder | Hangzhou | Zhejiang | 310010 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22160708 | Result | Eldaief MC, Halko MA, Buckner RL, Pascual-Leone A. Transcranial magnetic stimulation modulates the brain's intrinsic activity in a frequency-dependent manner. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21229-34. doi: 10.1073/pnas.1113103109. Epub 2011 Dec 12. | |
| 25170153 | Result | Wang JX, Rogers LM, Gross EZ, Ryals AJ, Dokucu ME, Brandstatt KL, Hermiller MS, Voss JL. Targeted enhancement of cortical-hippocampal brain networks and associative memory. Science. 2014 Aug 29;345(6200):1054-7. doi: 10.1126/science.1252900. |
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The IPD data cannot be shared with other researchers right now. We will shared it two years later.
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| 26602957 | Result | Wang J, Yang N, Liao W, Zhang H, Yan CG, Zang YF, Zuo XN. Dorsal anterior cingulate cortex in typically developing children: Laterality analysis. Dev Cogn Neurosci. 2015 Oct;15:117-29. doi: 10.1016/j.dcn.2015.10.002. |