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Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Healthy, term, non-obese (BMI < 30) pregnant women with a singleton gestation scheduled for CS delivery at 37-41 weeks of gestation. |
| |
| Study group 1 | Term pregnant, non-obese (BMI <30), diagnosed with gestational diabetes, scheduled for CS delivery between 37-41 weeks of gestation. |
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| Study group 2 | Term pregnant, obese (BMI >30), non-diabetic and scheduled for CS delivery between 37-41 weeks of gestation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adiponectin and TNFa | Biological | Adiponectin and TNFa are adipokines. Will be added to the myometrial biopsies to investigate their effect on the force of contractility |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effect on force of contractility | Determine the effect of adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Force of contractility between study groups | Compare the force of myometrial contractility in study groups compared to control group (non-DM, non-obese term pregnant patients) | 24 hours |
| Progesterone effect in control group |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant subjects undergoing a scheduled C-section delivery.
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| Name | Affiliation | Role |
|---|---|---|
| Katherine Jacobs, MD | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fairview Hospital | Minneapolis | Minnesota | 55344 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Feb 26, 2018 | Apr 11, 2018 | Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Feb 26, 2018 | Apr 11, 2018 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D052242 | Adiponectin |
| ID | Term |
|---|---|
| D054392 | Adipokines |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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Investigate the anti-inflammatory properties of Progesterone (P4) and 17a-Hydroxyprogesterone (HPC) on Adiponectin induced myometrial contractility in control group
| 24 hours |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |