Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype

Study of Role of Mononuclear Cells of Maternal Peripheric Blood in Human Myometrial Primar Cell Lines Differentiation Toward a Contratyl Phenotype: Influence of Preconceptional Obesity

The purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (Il-1B), then by studying the role of blood mononuclear cells, of leptine and of obese women sera to interfere with the transition of myometrial cells toward hyperplasia phenotype.

Inclusion Criteria:

• Informed consent signed
• Patient affiliated with a social security scheme
• In front of for obstetrical reasons to give birth by caesarean section (scheduled caesarean section)
• Or a woman who is not obese in labour and needs to undergo a cesarean section
• No obvious infectious context
• Age > 18 years old

Exclusion Criteria:

• Obvious inflammatory or autoimmune diseases
• Suspected or confirmed infectious context, including virale infection VIH, VHC, VHB
• Coagulation disorders