Preventing Recurrent Urinary Tract Infections With α-D-mannose

Preventing Recurrent Urinary Tract Infections With α-D-mannose: a Prospective, Randomized, Double-blinded Placebo-controlled Trial

In this trial, women with history of recurrent urinary tract infections (UTIs) will be followed over the course of 6 months. The women will be randomized either to D- Mannose or Placebo.

The primary objective of this study is to investigate if treatment with D-mannose reduces the risk for a UTI recurrence compared to treatment with Placebo.

H0: Women with history of recurrent UTIs treated with D-Mannose on average have the same number of recurrent UTIs over the course of 6 months compared to women treated with Placebo.

H1: Women with history of recurrent UTIs treated with D-Mannose on average have fewer recurrent UTIs over the course of 6 months compared to women treated with Placebo.

Inclusion Criteria:

• Women
• ≥ 3 UTIs within the last 12 months or ≥ 2 UTIs within the last 6 months;
• Laboratory urine culture: <103 CFUs
• Age > 18 years

Exclusion Criteria:

• UTIs ≥ 12 within 1 year
• Pregnancy or Lactation
• Immune disease
• Lactose intolerance
• Urinary tract anomaly
• Systemic infection
• Newly started hormone therapy within the last 6 months
• Antibiotic prophylaxis within the last 6 months
• α-D-mannose intake within the last month
• Use of catheters
• Diabetes mellitus
• Participation to other studies