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| Name | Class |
|---|---|
| Sistema Nacional de Investigadores de Panamá | UNKNOWN |
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To compare two protocols of misoprostol use for cervical ripening: 3 doses (25 ug vaginal each) or up to six doses, every six hours, until an adequate cervical condititon was achieved (BIshop score > 6). In the first group, after 3 doses, the patient was sent to the delivery room for induction with oxytocin and in case of failure, a cesarean section was indicated for this reason. In the second group, up to six doses were used in a similar fashion. Rates of success were evaluated, as well as maternal and fetal complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 6 Misoprostol | Experimental | Up to six doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score > 6. |
|
| 3 misoprostol | Active Comparator | Up to 3 doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score > 6. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 6 misoprostol | Procedure | Up to 6 doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score > 6. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vaginal birth | Number of patients that had a vaginal birth | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal complications | Number of patients that developed a maternal complication due to the use of misoprostol (abruptio placenta, postpartum bleeding, uterine atony). | 48 hours |
| Fetal complications |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Thomas Maternity Hospital | Panama City | Panama |
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| ID | Term |
|---|---|
| D000527 | Alprostadil |
| ID | Term |
|---|---|
| D011458 | Prostaglandins E |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
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| 3 misoprostol | Procedure | Up to 3 doses of 25ug of misoprostol applied every 6 hours. End point is cervical Bishop score > 6. |
|
|
Number of patients that developed a fetal complication due to the use of misoprostol (stillbirth, fetal distress).
| 48 hours |
| D005227 |
| Fatty Acids |
| D008055 | Lipids |
| D005229 | Fatty Acids, Monounsaturated |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |