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| ID | Type | Description | Link |
|---|---|---|---|
| KS2007 |
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This is a randomised study aimed at comparing the currently most frequently used prostaglandin dinoprostone to two other methods, the cheaper and perhaps more effective prostaglandin misoprostol and a transcervical catheter. 592 women were recruited and randomised to one of the three methods. The main outcome measures were time to delivery, rate of instrumental deliveries and maternal neonatal outcome. Our hypothesis was that misoprostol would be superior to the other methods.
The main finding of our trial was that the catheter showed the shortest induction to delivery interval. There were no differences between the two other prostaglandins. No differences in maternal and neonatal outcome was found
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Labour induction with misoprostol |
|
| 2 | Active Comparator | Labour induction with dinoprostone |
|
| 3 | Experimental | Labour induction with bard |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| misoprostol | Drug | 0.025mg tablet vaginally every 4 hour until progress |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time from treatment start to delivery | At delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lena Marions, MD PhD | Karolinska University Hospital Institute | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36996264 | Derived | de Vaan MD, Ten Eikelder ML, Jozwiak M, Palmer KR, Davies-Tuck M, Bloemenkamp KW, Mol BWJ, Boulvain M. Mechanical methods for induction of labour. Cochrane Database Syst Rev. 2023 Mar 30;3(3):CD001233. doi: 10.1002/14651858.CD001233.pub4. |
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| ID | Term |
|---|---|
| D016595 | Misoprostol |
| D013607 | Tablets |
| D015232 | Dinoprostone |
| C010714 | dinoprost tromethamine |
| ID | Term |
|---|---|
| D011459 | Prostaglandins E, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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| dinoprostone | Drug | 2mg vaginal gel every 6 hours until progress |
|
|
| Bard Catheter (balloon catheter) | Device | Intracervical balloon catheter positioned above internal cervical os and filled with sterile water. Removed when cervix was dilated |
|
|
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
| D011458 | Prostaglandins E |