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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL140574 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of the study is to compare dietary habits after bariatric surgery in patients with poor weight loss versus good weight loss outcomes.
The obesity epidemic is a major public health concern with a significant economic burden in the USA. Bariatric surgery is the most effective and durable weight loss treatment, with long-term cardiometabolic health benefits. Among different types of bariatric procedures, sleeve gastrectomy (SG) has become the most commonly performed in USA. While SG is expected to result in a 50-60% excess weight loss, inter-individual differences in weight loss are large and approximately 25% of patients can be considered poor weight-loss responders who either do not lose a substantial amount of weight or regain the lost weight afterwards. The mechanisms underlying this clinical variation remain unknown and interventions to improve on these outcomes critically lacking. Of interest, altered daily dietary habits are experienced by a substantial proportion of bariatric surgery candidates, raising the question whether such alterations may contribute to inter-individual differences in weight loss success. Therefore, the purpose of the study is to compare dietary habits after bariatric surgery in patients with different weight loss outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Weight loss < median of group | Sleeve gastrectomy surgery patients will take part in in-laboratory assessment. Based on 1-year post-surgical weight loss, a median split will be done to allocate subjects to one of two groups. |
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| Weight loss > median of group | Sleeve gastrectomy surgery patients will take part in in-laboratory assessment. Based on 1-year post-surgical weight loss, a median split will be done to allocate subjects to one of two groups. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In-laboratory assessment | Other | Participants will stay in the laboratory for two days and one night during which they will complete questionnaires, have blood drawn, and have other measurements taken. |
| Measure | Description | Time Frame |
|---|---|---|
| Self-rated hunger | Hunger measured from the visual analogue scale (VAS) questionnaire | One day of laboratory protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Self-rated appetite | Appetite measured from the visual analogue scale (VAS) questionnaire | One day of laboratory protocol |
| Appetite-regulating hormones | Appetite-regulating hormones from blood samples |
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Inclusion Criteria:
Exclusion Criteria:
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Patients that have undergone sleeve gastrectomy surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Frank Scheer, PhD | Brigham and Women's Hospital | Principal Investigator |
| Ali Tavakkoli, MD | Brigham and Women's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D005247 | Feeding Behavior |
| D001836 | Body Weight Changes |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Whole blood, urine, saliva.
| One day of laboratory protocol |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001522 | Behavior, Animal |
| D001519 | Behavior |