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| ID | Type | Description | Link |
|---|---|---|---|
| R01AA025936 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
| University of Pittsburgh | OTHER |
| Penn State University | OTHER |
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This study aims to identify risk factors that prospectively predict alcohol problems in young adults.
The vast majority of alcohol use takes place in social settings, yet nearly all human experimental work has administered alcohol to individuals in isolation. This study will examine the effects of alcohol in social groups and test whether these responses predict the escalation of alcohol use and development of alcohol use disorder symptoms. Participants will also complete smartphone surveys querying subjective responses to alcohol in their daily lives.
N=400 male and female young adults will participate in a laboratory session with two other participants and will consume either a moderate dose of alcohol or placebo beverage. Subjective and objective responses to alcohol will be assessed. Participants will also complete surveys on their smartphones; these will occur during drinking episodes and at random times throughout the day. Follow-up sessions will occur at 6-months and 12-months, to collect information about drinking habits and potential alcohol-related problems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alcohol Beverage | Experimental | Moderate dose of alcohol (target BAC .08%) |
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| Placebo Beverage | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol | Drug | target BAC .08% |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Alcohol Use at 12-months | Timeline Follow Back Method | 12-month follow-up |
| Change from Baseline Alcohol Use Disorder Symptoms at 12-months | Structured Clinical Interview for DSM-5 | 12-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective Responses to Alcohol | Participants will indicate how they feel after drinking alcohol using the Brief-Biphasic Alcohol Effects Scale, which is a 6-item scale assessing alcohol's acute stimulant and sedative effects (0-10 scale, with higher scores indicating higher values). | 1 day (laboratory session) and 21-day ambulatory assessment period |
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Inclusion Criteria:
Exclusion Criteria:
[Exclusion criteria are masked from public viewing until data collection is complete. Please contact project managers.]
May be either male or female, but must be same as gender assigned at birth.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Carnegie Mellon University | Pittsburgh | Pennsylvania | 15213 | United States |
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| D000437 | Alcoholism |
| D000435 | Alcoholic Intoxication |
| D063425 | Binge Drinking |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Other |
placebo beverage |
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| Social Bonding | Facial expressions of emotions using Paul Ekman's Facial Action Coding System (FACS). The duration of AUs associated with positive and negative affect will be coded. | 1 day (laboratory session) |
| Social Bonding | Perceived Group Reinforcement Scale, which is a 12-item scale assessing self-reported bonding (1-9 scale, with higher scores indicating more bonding). | 1 day (laboratory session) |
| Mood | 8-item Mood Measure, which is an 8-item scale assessing mood items from each of the four quadrants of the affective circumplex (with higher scores indicating more felt emotion). | 1 day (laboratory session) |
| Alcohol Use | Quantity of standard drinks consumed. | 21-day ambulatory assessment period |
| D064419 |
| Chemically-Induced Disorders |
| D001523 | Mental Disorders |