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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01AA013746 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
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This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beverage with Heavy Alcohol Dose | Experimental | Beverage containing 0.8 g/kg alcohol |
|
| Beverage with Low Alcohol Dose | Experimental | Beverage containing 0.4 g/kg alcohol |
|
| Beverage with No alcohol (Placebo) | Placebo Comparator | Beverage containing 0.0 g/kg alcohol to act as placebo |
|
| Beverage with Diphenhydramine | Experimental | Beverage containing 1.5 standard dose of Diphenhydramine (Benadryl) |
|
| Beverage with Caffeine | Experimental | Beverage containing the equivalent of 1.5 times participant's average caffeine consumption |
|
| Beverage in Natural Environment | No Intervention | Participant consumes alcohol containing beverages or non-alcohol beverages in natural environment |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ethanol | Drug | Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers | Measured during 5 timepoints at each experimental session: 1) Pre-drink baseline, 2) +30 minutes, 3) +60 minutes, 4) +120 minutes, and 5) +180 minutes following the initiation of beverage consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Substance Use Behavior Reported During Follow-Up Interviews | Measured at 3, 6, 9, 12, 15, 18, 21, 24, 36, 48, and 60 months following the final experimental session |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrea C King, PhD | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Addictions Research Laboratory | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15000501 | Background | King AC, Byars JA. Alcohol-induced performance impairment in heavy episodic and light social drinkers. J Stud Alcohol. 2004 Jan;65(1):27-36. doi: 10.15288/jsa.2004.65.27. | |
| 12068251 | Background | King AC, Houle T, de Wit H, Holdstock L, Schuster A. Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res. 2002 Jun;26(6):827-35. |
| Label | URL |
|---|---|
| Study Website | View source |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| C026285 | trichlorosucrose |
| D004155 | Diphenhydramine |
| D002110 | Caffeine |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D005021 | Ethylamines |
| D000588 | Amines |
| D001559 |
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| Placebo | Drug | Beverage containing 0.0 g/kg alcohol to act as placebo |
|
| Diphenhydramine | Drug | Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl) |
|
|
| Caffeine | Drug | Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake |
|
| 19320625 | Result | Rueger SY, McNamara PJ, King AC. Expanding the utility of the Biphasic Alcohol Effects Scale (BAES) and initial psychometric support for the Brief-BAES (B-BAES). Alcohol Clin Exp Res. 2009 May;33(5):916-24. doi: 10.1111/j.1530-0277.2009.00914.x. Epub 2009 Mar 11. |
| 16804691 | Result | Epstein AM, Sher TG, Young MA, King AC. Tobacco chippers show robust increases in smoking urge after alcohol consumption. Psychopharmacology (Berl). 2007 Feb;190(3):321-9. doi: 10.1007/s00213-006-0438-8. Epub 2006 Jun 28. |
| 17560739 | Result | Brumback T, Cao D, King A. Effects of alcohol on psychomotor performance and perceived impairment in heavy binge social drinkers. Drug Alcohol Depend. 2007 Nov 2;91(1):10-7. doi: 10.1016/j.drugalcdep.2007.04.013. Epub 2007 Jun 8. |
| 18770076 | Result | King A, Epstein A, Conrad M, McNamara P, Cao D. Sex differences in the relationship between alcohol-associated smoking urge and behavior: a pilot study. Am J Addict. 2008 Sep-Oct;17(5):347-53. doi: 10.1080/10550490802268140. |
| 15834219 | Result | King AC, Epstein AM. Alcohol dose-dependent increases in smoking urge in light smokers. Alcohol Clin Exp Res. 2005 Apr;29(4):547-52. doi: 10.1097/01.alc.0000158839.65251.fe. |
| 33397141 | Result | King A, Vena A, Hasin DS, deWit H, O'Connor SJ, Cao D. Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. Am J Psychiatry. 2021 Jun;178(6):560-571. doi: 10.1176/appi.ajp.2020.20030247. Epub 2021 Jan 5. |
| 31685074 | Derived | King AC, Cao D, deWit H, O'Connor SJ, Hasin DS. The role of alcohol response phenotypes in the risk for alcohol use disorder. BJPsych Open. 2019 Apr 22;5(3):e38. doi: 10.1192/bjo.2019.18. |
| 26117308 | Derived | King AC, Hasin D, O'Connor SJ, McNamara PJ, Cao D. A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry. 2016 Mar 15;79(6):489-98. doi: 10.1016/j.biopsych.2015.05.007. Epub 2015 May 14. |
| 24094754 | Derived | King AC, McNamara PJ, Hasin DS, Cao D. Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry. 2014 May 15;75(10):798-806. doi: 10.1016/j.biopsych.2013.08.001. Epub 2013 Oct 2. |
| 21464363 | Derived | King AC, de Wit H, McNamara PJ, Cao D. Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry. 2011 Apr;68(4):389-99. doi: 10.1001/archgenpsychiatry.2011.26. |
| Benzhydryl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |