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The study determined the effects of predominately resistance type exercise in combination with protein supplements on parameters of sarcopenia and osteopenia (sarco-osteopenia) in older, community dwelling men with sarcopenia and -osteopenia over 18 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exercise and protein supplementation | Experimental | Predominately resistance exercise training 2-3x week for 18 months; 1.5-1.7 g/kg/d total protein supplementation, Calcium and Vitamin-D-supplementation (i.e. 800 mg/800 IE/d) |
|
| control | No Intervention | Calcium and Vitamin-D-supplementation (i.e. 800 mg/800 IE/d) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise | Other | 3x week predominately resistance exercise for 18 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lumbar spine Bone Mineral Density (QCT) | Lumbar spine Bone Mineral Density as determined by Quantitative Computed Tomography | changes from baseline to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Lumbar spine Bone Mineral Density (DXA) | Lumbar spine Bone Mineral Density as determined by dual-energy x-ray absorptiometry (DXA) | changes from baseline to 12 and 18 months |
| Femoral Neck Bone Mineral Density |
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Inclusion Criteria:
Exclusion Criteria:
SD: Standard Deviation
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| Name | Affiliation | Role |
|---|---|---|
| Klaus Engelke, PhD | Institute of Medical Physics, University of Erlangen-Nürnberg, Germany | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Medical Physics, University of Erlangen-Nürnberg, Germany | Erlangen | 91052 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25963237 | Background | Kemmler W, Bebenek M, Kohl M, von Stengel S. Exercise and fractures in postmenopausal women. Final results of the controlled Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2015 Oct;26(10):2491-9. doi: 10.1007/s00198-015-3165-3. Epub 2015 May 12. | |
| 29125144 | Background | Kemmler W, von Stengel S. Bone: High-intensity exercise to prevent fractures - risk or gain? Nat Rev Endocrinol. 2018 Jan;14(1):6-8. doi: 10.1038/nrendo.2017.148. Epub 2017 Nov 10. No abstract available. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Outcome assessor are not aware of participant status and are nor allowed to ask correspondingly
Total hip Bone Mineral Density as determined by dual-energy x-ray absorptiometry (DXA)
| changes from baseline to 12 and 18 months |
| Skeletal muscle mass index | Skeletal muscle mass as defined fat and bone free mass of the limbs as determined by DXA divided by square height | changes from baseline to 6, 12 and 18 months |
| Gait velocity | Habitual gait speed over 10 m | changes from baseline to 6, 12 and 18 months |
| Hand-grip strength | Maximum hand-grip strength of the dominant and non-dominant hand as assessed by a Jamar dynamometer | changes from baseline to 6, 12 and 18 months |
| Hip and leg extensor strength | Maximum dynamic hip and leg extensor strength as determined by a isokinetic leg press | changes from baseline to 6, 12 and 18 months |
| Muscle Density at the calf, thigh and para-vertebral site | Muscle Density at the calf, thigh and para-vertebral site as assessed by MRI | changes from baseline to 6 and 12 months |
| 27108341 | Background | Kemmler W, von Stengel S, Kohl M. Exercise frequency and bone mineral density development in exercising postmenopausal osteopenic women. Is there a critical dose of exercise for affecting bone? Results of the Erlangen Fitness and Osteoporosis Prevention Study. Bone. 2016 Aug;89:1-6. doi: 10.1016/j.bone.2016.04.019. Epub 2016 Apr 21. |
| 38326734 | Derived | Kircher K, Chaudry O, Nagel AM, Ghasemikaram M, Uder M, Jakob F, Kohl M, Kemmler W, Engelke K. Effects of high-intensity training on fatty infiltration in paraspinal muscles in elderly males with osteosarcopenia - the randomized controlled FrOST study. BMC Geriatr. 2024 Feb 8;24(1):141. doi: 10.1186/s12877-024-04736-5. |
| 33408874 | Derived | Kemmler W, Kohl M, von Stengel S, Schoene D. Effect of high-intensity resistance exercise on cardiometabolic health in older men with osteosarcopenia: the randomised controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). BMJ Open Sport Exerc Med. 2020 Dec 24;6(1):e000846. doi: 10.1136/bmjsem-2020-000846. eCollection 2020. |
| 33249320 | Derived | Kemmler W, Kohl M, Frohlich M, Schoene D, von Stengel S. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2021 Jan;142:115772. doi: 10.1016/j.bone.2020.115772. Epub 2020 Nov 26. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |