Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Ludwig-Maximilians - University of Munich | OTHER |
| University Medical Center Rostock | OTHER |
| Praxis Endokrinologie in Charlottenburg, Berlin | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status. To further investigate general morbidity, hypocalcemic events, subjective and daily life performance in patients with chronic hypoparathyroidism a disease specific questionnaire, as well as the SF-36 are handed out.
Design:
In a cross-sectional trial the subjective health status and burden of illness in patients with chronic hypoparathyroidism will be evaluated by using a disease specific questionnaire as well as the SF-36.
Patients:
Patients will be recruited out of the patient population of the participating five medical centers.
Statistical Analysis:
Documentation and analysis will be performed at the Department of Medicine I, Endocrine and Diabetes Unit, University of Würzburg, Germany. Data will be documented after pseudonymisation in a data base. For further analysis data will be compared to sex- and age-matched controls.
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Burden of illness | Assessment of the burden of illness due to chronic hypoparathyroidism using a disease specific questionnaire to further investigate impairment in daily and professional life in comparison to the general German population (DEGS1, SHIP-2). | 12 - 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Hypocalcemia | documentation of frequency of hypocalcemia under standard treatment | 12 - 24 months |
| Psychological disorders | documentation of frequency of anxiety and depression under standard treatment |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
patients with chronic hypo- and pseudohypoparathyroidism
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stefanie Hahner, MD | Wuerzburg University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Endokrinologie in Charlottenburg | Berlin | D-10627 | Germany | |||
| Charite Berlin |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11834431 | Background | Arlt W, Fremerey C, Callies F, Reincke M, Schneider P, Timmermann W, Allolio B. Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol. 2002 Feb;146(2):215-22. doi: 10.1530/eje.0.1460215. | |
| 24449664 | Background | Hadker N, Egan J, Sanders J, Lagast H, Clarke BL. Understanding the burden of illness associated with hypoparathyroidism reported among patients in the PARADOX study. Endocr Pract. 2014 Jul;20(7):671-9. doi: 10.4158/EP13328.OR. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007011 | Hypoparathyroidism |
| D010279 | Parathyroid Diseases |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
Not provided
Not provided
| Charite University, Berlin, Germany |
| OTHER |
| Endocrine Practice, Oldenburg, Germany | UNKNOWN |
Not provided
Not provided
Not provided
| 12 - 24 months |
| Subjective Health Status | Assessment of the subjective health status due to chronic hypoparathyroidism by Assessment of subjective health status in patients with chronic hypoparathyroidism | 12-24 months |
| Berlin |
| Germany |
| Ludwig-Maximilians-Universität | Munich | 81377 | Germany |
| University Hospital Rostock | Rostock | 18057 | Germany |
| Dept. of Endocrinology and Diabetology, Dept. of Medicine I, University Hospital Wuerzburg | Würzburg | 97080 | Germany |
| 41987889 | Derived | Fuss CT, Engbers S, Reisch N, Hannemann A, Volzke H, Grabe HJ, Nauck M, Droste M, Willenberg HS, Rayes N, Fassnacht M, Quinkler M, Hahner S. Subjective health status, life performance and complications in chronic hypoparathyroidism - a German multicenter survey. Front Endocrinol (Lausanne). 2026 Mar 31;17:1723640. doi: 10.3389/fendo.2026.1723640. eCollection 2026. |