The purpose of this study is to evaluate the evolution of the non specific symptoms for 116 patients with mild primary hyperparathyroidism before and 3, 6 and 12 months after surgery. A clinical score predicting clinical improvement at one year will be created.

Inclusion Criteria:

• Subjects with known moderate HPTI will be considered for participation.

Patients with sporadic mild HPTI defined by:

• calcemia > 2.6 mmol/L , PTH > 25 ng/L and creatininemia < 160µmol/L OR
• calcemia between 2.5 and 2.6 mmol/L and PTH > 35 ng/L
• calcemia ≤2.85 mmol/L
• urine calcium level / 24 hours < 10 mmol (400 mg),
• decrease of the creatinin's clearance : 30% lower than normal population with the same age
• patients younger than 50
• patients who can't be followed

Exclusion Criteria:

• familial hypercalcemia
• multiple endocrinal neoplasia
• treatment with lithium or thiazides
• impossibility for the patient to complete the forms
• impossibility to follow the patient
• patient with serious disease which impact the quality of life

A prospective, non randomized, open, multicenter trial to evaluate non specific symptoms and quality of life (SF 36) before and after surgery for mild primary hyperparathyroidism