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Comparison of coated and uncoated TKA with regard to cytokine expression and clinical results
Comparison of coated and uncoated TKA with regard to cytokine expression and clinical results at 3 months, 1 year and 3 years after surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coated Total Knee Arthroplasty | Experimental | Implantation coated Total Knee Arthroplasty |
|
| Standard Total Knee Arthroplasty | Active Comparator | Implantation Standard Total Knee Arthroplasty |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coated Total Knee Arthroplasty | Device | Implantation coated Total Knee Arthroplasty |
|
| Measure | Description | Time Frame |
|---|---|---|
| cytokine expression | Changes of cytokine expression 1 and 3 years after surgery compared to pre-op | pre-op, 1 and 3 years post-op |
| Measure | Description | Time Frame |
|---|---|---|
| Function assessed with Knee Society Score | Knee Society Score (0 - 100 points, best 100) | pre-op, 3 months, 1 and 3 years post-op |
| Patient reported outcome assessed with Oxford Knee Score | Oxford Knee Score (0 - 48 points, best 48) |
| Measure | Description | Time Frame |
|---|---|---|
| adverse events | adverse events | 3 month, 1 year and 3 years post-op |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jörg Lützner, MD | University Center of Orthopaedics and Traumatology, University Medicine Carl Gustav Carus Dresden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Center of Orthopaedics and Traumatology, University Medicine Carl Gustav Carus Dresden, TU Dresden | Dresden | Saxony | 01307 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38098024 | Derived | Tille E, Beyer F, Lutzner C, Postler A, Thomas P, Summer B, Lutzner J. No difference in patient reported outcome and inflammatory response after coated and uncoated total knee arthroplasty - a randomized controlled study. BMC Musculoskelet Disord. 2023 Dec 14;24(1):968. doi: 10.1186/s12891-023-07061-x. |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| Standard Total Knee Arthroplasty | Device | Implantation StandardTotal Knee Arthroplasty |
|
| pre-op, 3 months, 1 and 3 years post-op |
| Quality of life assessed with EQ 5D | EQ 5D Index (0 - 1.0, best 1.0) | pre-op, 3 months, 1 and 3 years post-op |
| Activity assessed with UCLA activity score | UCLA activity score (0 - 10 points, best 10) | pre-op, 3 months, 1 and 3 years post-op |