Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the study group. These patients underwent total knee arthroplasty

Twenty-two patients (female/male:13/9) with \

Osteoarthritis (OA) is one of the most common chronic peripheral joint diseases increasing among the aging population.Pathogenesis is not fully known.One of the most common risk factors and causes are loss of pain and function. Knee joint osteoarthritis adversly affects the person's life quality. Total Knee Arthroplasty (TKA) is a surgical approach to restore tibiofemoral joint alignment, especially in the severe level of knee OA.

Systemic venous blood samples were taken. IL-6, TNF-α and IL-1β cytokine levels were examined.

The pain intensity were evaluated by the Visuel Analog Scale.

The Western Ontario and McMaster Universities Arthritis Index was used for functional status.

Electro-goniometer was used for proprioception evaluation

In this evaluation, the valgity angle and the malalingement amount were calculated on the knee antero-posterior direct X-ray imageby an experienced orthopedist