Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

The Relation Between Systemic Inflammatory Markers and Acute Pain in TKA

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.

Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).

We pole blood-samples collected prospectively (from two data set)

Inclusion Criteria:

• Elective unilateral primary total knee arthroplasty
• Able to speak and understand danish
• Able to give informed consent

Exclusion Criteria:

• Alcohol or medical abuse
• Allergies to local anesthetics or methylprednisolone
• Age < 18 years old
• Daily use of strong opioids or glucocorticoids
• Pregnancy or breastfeeding (fertile women)
• Bilateral / revision arthroplasty
• Dementia or other cognitive dysfunction
• Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception