Serum Metal Ion Concentration After Total Knee Arthroplasty (TKA)

A Prospective Randomized Comparison of Serum Metal Ion Levels After Implantation of Coated and Uncoated Knee Prostheses

All metal implants release metal ions because of corrosion. Total knee arthroplasty implants have large metal surface areas and therefore substantial potential for corrosion. It is planned to compare changes in serum levels of metal ions in patients after implantation of cemented unconstrained total knee arthroplasty covered with or without a passivating surface. Serum concentrations of chromium, cobalt, molybdenum and nickel will be analyzed and compared between the two groups, as well as with those of 130 control patients without implants.

Inclusion Criteria:

• Indication for TKA in primary oder secondary osteoarthritis of the knee
• Patient's consent

Exclusion Criteria:

• Additional Implants present
• Allergy against constituents of implant or cement
• Any malignancies
• Renal insufficiency
• Any additional serious disease complicating the participation in this study