Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.

Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Inclusion Criteria:

• Major gastrointestinal surgery
• Assumed need of post-operative artificial nutrition.

Exclusion Criteria:

• Insulin dependent diabetes
• Steroid medication