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Preoperative optimization of patients is a well known concept. Not all patients can tolerate feeds and as such TPN is given. TPN given preoperatively and continued postoperatively in selected group of patients can significantly improve the surgical outcomes and lower the morbidity as well as mortality. So the investigators aim to find the impact of TPN in malnutritional surgical patients.
Any patient who is at risk of malnutrition as well as already malnutritioned were given preoperative TPN for 5 days. After 5 days, elective surgery was done and TPN was continued postoperatively until patient could consume 50% of their daily requirements orally. Patients who underwent emergency surgeries were also enrolled in this study as these patients could receive TPN only postoperatively.
Daily patient charting with Clavien Dindo Classification, length of stay and mortality were mentioned and verified by the operating surgical team.
Data was maintained electronically by the surgical team. Data was also entered in MS-EXCEL at the time of patient discharge. Since data was maintained on everyday basis till patient discharge and does not include follow-ups, there are no missing data.
Upon completion of study, all data will be exported to SPSS and analyzed accordingly using means, SDs, Chi-square and Fisher exact test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Malnutrition | All malnutrition patients to received TPN for 5 days preoperatively as applicable and continued postoperatively. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TPN-N7 Baxter | Dietary Supplement | providing TPN to all malnutrition patients preoperatively as well as postoperatively. |
|
| Measure | Description | Time Frame |
|---|---|---|
| studying the effects of TPN on length of hospital stay | comparison of perioperative and postoperative TPN in terms of mean length of stay in days | through study completion, an average of 5years |
| studying the effects of TPN on mortality | comparison of perioperative and postoperative TPN in terms of number of mortality cases | through study completion, an average of 5years |
| studying the effects of TPN on complications using grades | comparison of perioperative and postoperative TPN in terms of Clavien-Dindo classification grades | through study completion, an average of 5years |
| studying the effect of albumin levels on length of hospital stay | comparison of low and normal albumin levels in terms of mean length of stay in days | through study completion, an average of 5years |
| studying the effect of albumin levels on mortality | comparison of low and normal albumin levels in terms of number of mortality cases | through study completion, an average of 5years |
| studying the effect of albumin levels on complication using grades | comparison of low and normal albumin levels in terms of Clavien-Dindo Classification grades | through study completion, an average of 5years |
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Inclusion Criteria:
Exclusion Criteria:
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All patients presenting to the Surgery department at Nepal Medical College teaching hospital and having malnutrition.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nepal Medical College Teaching Hospital | Kathmandu | Bagmati | Nepal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20375423 | Background | Jensen GL, Mirtallo J, Compher C, Dhaliwal R, Forbes A, Grijalba RF, Hardy G, Kondrup J, Labadarios D, Nyulasi I, Castillo Pineda JC, Waitzberg D; International Consensus Guideline Committee. Adult starvation and disease-related malnutrition: a proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. JPEN J Parenter Enteral Nutr. 2010 Mar-Apr;34(2):156-9. doi: 10.1177/0148607110361910. | |
| 26688128 |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 21, 2022 | Aug 23, 2024 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D006963 | Hyperphagia |
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009748 | Nutrition Disorders |
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| Background |
| Thomas MN, Kufeldt J, Kisser U, Hornung HM, Hoffmann J, Andraschko M, Werner J, Rittler P. Effects of malnutrition on complication rates, length of hospital stay, and revenue in elective surgical patients in the G-DRG-system. Nutrition. 2016 Feb;32(2):249-54. doi: 10.1016/j.nut.2015.08.021. Epub 2015 Sep 25. |
| 32384662 | Background | Lakananurak N, Gramlich L. The Role of Preoperative Parenteral Nutrition. Nutrients. 2020 May 6;12(5):1320. doi: 10.3390/nu12051320. |
| 27112357 | Background | Zhao XF, Wu N, Zhao GQ, Liu JF, Dai YF. Enteral nutrition versus parenteral nutrition after major abdominal surgery in patients with gastrointestinal cancer: a systematic review and meta-analysis. J Investig Med. 2016 Jun;64(5):1061-74. doi: 10.1136/jim-2016-000083. Epub 2016 Apr 25. |
| D009750 | Nutritional and Metabolic Diseases |