Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics

Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics

The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition

Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Inclusion Criteria:

• Major gastrointestinal surgery.
• Assumed need of post-operative nutrition support.

Exclusion Criteria:

• Insulin dependent diabetes.
• Steroid medication.