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administrative hurdles
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Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases in children
Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy controls | Children without eye disease |
| |
| Retinopathy of prematurity (ROP) | Previously preterm children with a history of ROP |
| |
| Diabetic retinopathy | Children with diabetes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OCT-A | Device | optical coherence tomography angiography Imaging with optical coherence tomography angiography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the sensitivity and specificity of OCTA | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Participants with a history of clinically diagnosed retinal diseases and healthy individuals undergoing ophthalmic Imaging in Routine clinical practice will be included
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| ID | Term |
|---|---|
| D012178 | Retinopathy of Prematurity |
| D003930 | Diabetic Retinopathy |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D007235 | Infant, Premature, Diseases |
| D007232 | Infant, Newborn, Diseases |
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| D009358 |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003925 | Diabetic Angiopathies |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |