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Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetic retinopathy | Patients with various degrees of diabetic retinopathy |
| |
| Retinal detachment | Patients with a history of retinal detachment |
| |
| Retinal vein occlusion | Patients with a history of retinal vein occlusion |
| |
| Arterial hypertension | Patients with a history of arterial hypertension |
| |
| Carotid artery occlusion | Patients with a history of carotid artery occlusion |
| |
| Age related macular degeneration | Patients with a history of Age related macular degeneration |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| optical coherence tomography angiography | Device | Imaging with optical coherence tomography angiography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the sensitivity and specificity of OCTA | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. |
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Inclusion criteria:
Patients from the Department of Ophthalmology, University Hospital Bern requiring conventional imaging for eye disease and willing to sign informed consent Patients of 18 years or older
Exclusion criteria:
Patients not willing or able to sign informed consent Patients younger than 18 years Patients with epilepsy Patients having had photodynamic therapy within the last 48 hours prior to imaging with OCTA
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Participants with a history of clinically diagnosed retinal diseases, including but not limited to age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, macular macroaneurysma, and diabetic macular edema and healthy individuals undergoing ophthalmic Imaging in Routine clinical practice will be included
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| Name | Affiliation | Role |
|---|---|---|
| Martin Zinkernagel, Prof.MD PhD | Inselspital, University Clinic for Ophthalmology | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inselspital Bern, Department of Ophthalmology | Bern | 3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36627172 | Derived | Tian M, Zeng G, Zinkernagel M, Tappeiner C, Wolf S, Munk MR. Assessment of choriocapillaris and choroidal vascular changes in posterior uveitis using swept-source wide-field optical coherence tomography angiography. Br J Ophthalmol. 2024 Feb 21;108(3):386-390. doi: 10.1136/bjo-2022-322209. | |
| 30538102 | Derived |
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| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| Macroaneurysms | Patients with a history of retinal macroaneurysms |
|
| Central serous chorioretinopathy | Patients with a history of central serous chorioretinopathy |
|
| 2 years |
| OCTA and Fundus color photographs | Evaluation whether pathological changes seen in OCT or color fundus photography correlate with changes seen in OCTA | 2 years |
| Subgroup analysis | Subgroup analysis will be performed with patients suffering from diabetic retinopathy, artery occlusion, carotid stenosis, retinal detachment, vein occlusion, age related macular degeneration, retinal changes from arterial hypertension, retinal macroaneurysms and uveitis. | 2 years |
| Tian M, Tappeiner C, Zinkernagel MS, Huf W, Wolf S, Munk MR. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography. Br J Ophthalmol. 2019 Sep;103(9):1289-1295. doi: 10.1136/bjophthalmol-2018-313078. Epub 2018 Dec 11. |