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| Name | Class |
|---|---|
| Ministry of Health, Iraq | NETWORK |
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Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.
The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zinc sulfate | Experimental | 60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg). |
|
| Healthy control | No Intervention | 60 fertile (age 31.6±3.3 year) men, no treatment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zinc Sulfate | Dietary Supplement | The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer. | Clinical parameter | up to three months. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer. | Enzyme | up to three months. |
| Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer. |
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Inclusion Criteria:
Exclusion Criteria:
Male that undergo the presence of asthenozoospermia in the semen sample.
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| Name | Affiliation | Role |
|---|---|---|
| Abdul Razzaq A. Alsalman, PhD | University of Babyblon | Study Chair |
| Lamia A. Almashhedy, PhD | University of Babyblon | Study Director |
| Mahmoud Hussein Hadwan, PhD | University of Babyblon | Principal Investigator |
| Abdulsamie H Alta'ee, PhD | University of Babyblon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mahmoud Hussein Hadwan | Hillah | Babylon | 51002 | Iraq |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31710193 | Derived | Alsalman ARS, Almashhedy LA, Alta'ee AH, Hadwan MH. Effect of Zinc Supplementation on Urate Pathway Enzymes in Spermatozoa and Seminal Plasma of Iraqi Asthenozoospermic Patients: A Randomized Controlled Trial. Int J Fertil Steril. 2020 Jan;13(4):315-323. doi: 10.22074/ijfs.2020.5760. Epub 2019 Nov 11. |
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| ID | Term |
|---|---|
| D053627 | Asthenozoospermia |
| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D019287 | Zinc Sulfate |
| ID | Term |
|---|---|
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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Semen volume after treatment.
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Enzyme
| up to three months. |
| Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer. | Enzyme | up to three months. |
| D007246 |
| Infertility |
| D052801 | Male Urogenital Diseases |
| D007287 |
| Inorganic Chemicals |
| D017967 | Zinc Compounds |