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| Name | Class |
|---|---|
| Ministry of Health, Iraq | NETWORK |
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Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.
The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zinc sulfate | Experimental | 60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate,every participant took two capsules of zinc sulfate per day for three months (each one 220 mg). |
|
| Healthy control | No Intervention | 60 fertile (age 31.6±3.3 year) men, no treatment |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| zinc sulfate | Dietary Supplement | The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels. | up to three months. |
| Measure | Description | Time Frame |
|---|---|---|
| Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels. | up to three months. | |
| Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mahmoud Hadwan, PhD | Babylon University | Principal Investigator |
| L Almashhedy, PhD | Babylon University | Study Director |
| Alsalman Abdulrrazaq, PhD | Babylon University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mahmoud Hadwan | Hillah | Babylon | 51002 | Iraq |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29222649 | Derived | Alsalman ARS, Almashhedy LA, Hadwan MH. Effect of Oral Zinc Supplementation on the Thiol Oxido-Reductive Index and Thiol-Related Enzymes in Seminal Plasma and Spermatozoa of Iraqi Asthenospermic Patients. Biol Trace Elem Res. 2018 Aug;184(2):340-349. doi: 10.1007/s12011-017-1215-8. Epub 2017 Dec 8. |
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I plan to publish the results in a scientific journal
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| ID | Term |
|---|---|
| D053627 | Asthenozoospermia |
| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D019287 | Zinc Sulfate |
| ID | Term |
|---|---|
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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| up to three months. |
| D007246 |
| Infertility |
| D052801 | Male Urogenital Diseases |
| D007287 |
| Inorganic Chemicals |
| D017967 | Zinc Compounds |