Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients

Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients

At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.

Inclusion Criteria:

General

• Adult
• Receiving beta-lactam antibiotic Piperacillin/Tazobactam
• Antibiotic therapy of 3 or more days
• Given informed consent Group 1
• Severe Burn Group 2
• No Severe Burn

Exclusion Criteria:

• Already in another Study
• No useful blood sample