Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In this project, intensive care unit (ICU) patients treated with beta-lactam antibiotics are included with the aim to investigate the potential underdosing in this patient group. Four regional ICU-clinics are recruiting consecutive patients (n=120) and samples are taken before the next dose is administered for three consecutive days.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention. | Other |
| Measure | Description | Time Frame |
|---|---|---|
| The rate of patients below 16mg/L for piperacillin-tazobactam, 2 mg/L for meropenem and 4mg/L for cefotaxim | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality in relation to initial levels of beta-lactam antibiotics as defined in primary outcome | 30 days | |
| The rate of patients below 100% time over MIC in relation to the bacteria causing the infection. | 3 days |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Intensive care unit patients treated with beta-lactam antibiotics
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Thomas Schön, MD PhD | Linkoeping University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Intensive care unit | Jönköping | Jönköping County | 391 85 | Sweden | ||
| Intensive Care Unit |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24045886 | Background | Udy AA, Roberts JA, Lipman J. Clinical implications of antibiotic pharmacokinetic principles in the critically ill. Intensive Care Med. 2013 Dec;39(12):2070-82. doi: 10.1007/s00134-013-3088-4. Epub 2013 Sep 18. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
Not provided
Not provided
Not provided
Not provided
Not provided
Plasma samples at three consecutive days for measurement of plasma drug concentrations
| Kidney function measured as eGFR in relation to initial levels of beta-lactam antibiotics as defined in primary outcome | 3 days |
| SAPS-score in relation to initial levels of beta-lactam antibiotics as defined in primary outcome | 3 days |
| Days in intensive care unit in relation to initial levels of beta-lactam antibiotics as defined in primary outcome | 30 days |
| Kalmar |
| Kalmar County |
| 39185 |
| Sweden |
| Intensive Care Unit | Linköping | Linköping | 581 85 | Sweden |
| Intensive care unit | Vaxjo | Växjö | 391 85 | Sweden |
| D013568 |
| Pathological Conditions, Signs and Symptoms |