The goal of this clinical trial is to compare in acute burn patients.

The main question it aims to answer are:

• what is the impact of early prophylactic use of antibiotics on prognosis Participants will be randomly divided into an antibiotic group and a non antibiotic group.

Researchers will compare the two groups to see the 72 hour wound bacterial culture negative rate.

Inclusion Criteria:

• Signed and dated informed consent form
• Promise to comply with research procedures and cooperate with the implementation of full process research
• Age 18 and above
• Emergency hospitalization of patients in the burn department, within 24 hours after injury
• No immunodeficiency disease, no history of using immunosuppressive drugs, no antibiotics being used or infectious diseases at the time of admission
• If a woman is in the reproductive period, she should not be pregnant

Exclusion Criteria:

• Unable to obtain informed consent from subjects, family members, or authorized agents
• At the time of admission, antibiotics were being administered
• During pregnancy
• Presence of infectious diseases before admission
• Existence of immunodeficiency diseases or use of immunosuppressive drugs
• The subjects are currently undergoing other clinical studies

Participants do not know which group they will be assigned to.