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Despite the explosive popularity of sweet flavored electronic cigarettes, there is little empirical evidence regarding how "sweet" flavors interact with different levels of nicotine to reduce its perceived bitterness and harshness, and thereby increase its appeal and additive potential. This study will serve to fill this knowledge gap through empirical psychophysical data that will determine the association between sweet flavor and nicotine and its link to the acceptance and rejection of vaped nicotine.
We will recruit current, healthy e-cigarette users between the ages of 18-35.This study will require 1 visit to the Oregon State University campus to partake in a 1 hour (approximate) testing session. During the testing session, participants will be asked to puff commercial e-cigarettes containing 9 commercially available e-liquid preparations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| E-cigarette | Other | Subjects will be asked to vape various e-cigarettes at three concentrations of nicotine and sweet flavor (9 stimuli per subject). The subject will be asked to make ratings for the overall liking or disliking of the e-cigarette, followed by ratings on perceived intensities of sensations. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| E-cigarettes with varying concentrations of nicotine & flavor | Other | Subjects will be asked to vape various e-cigarettes containing e-liquids at three concentrations of nicotine and sweet flavor (9 stimuli per subject). |
| Measure | Description | Time Frame |
|---|---|---|
| Hedonic and Intensity Ratings | The outcome will be ratings obtained for liking or disliking of the stimulus and ratings for perceived intensities of sensations. These quantitative values collected from the scaling procedure will be analyzed corresponding to the level of nicotine and flavor for the particular stimulus. For rating perceived intensity, we will use the general Labeled Magnitude Scale (gLMS), developed for measurement of the intensity of oral sensation and taste. The scale is bounded by 'no sensation' at the bottom to 'strongest imaginable sensation of any kind' on top, with intermediate ratings between (bottom to top: barely detectable, weak, moderate, strong, very strong). A Labeled Hedonic Scale (LHS) will be used to measure individuals' liking or disliking of the oral sensation. The scale encompasses from "most disliked sensation imaginable" on one end to "most liked sensation imaginable" on the other end, with intermediate hedonic labels (like/dislike: slightly, moderately, very much, extremely). | Until July 2018 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Juyun Lim | Oregon State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oregon State University | Corvallis | Oregon | 97330 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Mar 26, 2018 | Sep 30, 2019 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D012907 | Smoking |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D066300 | Electronic Nicotine Delivery Systems |
| D005421 | Flavoring Agents |
| ID | Term |
|---|---|
| D000074602 | Smoking Devices |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D010592 | Pharmaceutic Aids |
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| D004364 | Pharmaceutical Preparations |
| D005503 | Food Additives |
| D000074385 | Food Ingredients |
| D020313 | Specialty Uses of Chemicals |
| D020164 | Chemical Actions and Uses |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |