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Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing injection pain during propofol induction in elderly patients by the Dixon's up-and-down method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elderly | Experimental | Remifentanil was infused at predetermined effect-site concentration before propofol infusion in elderly patients. |
|
| Adult | Active Comparator | Remifentanil was infused at predetermined effect-site concentration before propofol infusion in adult patients. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil | Drug | Remifentanil was infused at predetermined effect-site concentration prior to propofol infusion (initial concentration: 3.0 ng/ml) in elderly patients (65-80 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Severity of propofol injection pain-4 point scale | 0 = no pain (negative response to questioning),
| during 3 min after remifentanil and propofol infusion to reach the equilibrium of plasma and effect-site concentration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong Yeop Kim | Ajou University Hospital, Suwon, Gyeongki-do, South Korea, 443-721 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jong Yeop Kim | Suwon | Gyeonggi-do | 443-721 | South Korea |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Remifentanil | Drug | Remifentanil was infused at predetermined effect-site concentration prior to propofol infusion (initial concentration: 3.0 ng/ml) in adult patients (20-60 years) |
|
|
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |