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Explore the effect of remifentanil on pruritus and paresthesia induced by fospropofol disodium in adults
Explore the effect of remifentanil on pruritus and paresthesia caused by fospropofol disodium in adults, to observe the manifestations and duration of pruritus and paresthesia
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group R1 | Experimental | remifentanil 0.5μg/kg |
|
| Group R2 | Experimental | remifentanil 1.0μg/kg |
|
| Group R3 | Experimental | remifentanil 1.5μg/kg |
|
| Group R4 | Experimental | remifentanil 2.0μg/kg |
|
| Group S | Active Comparator | sufentanil 0.3μg/kg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil | Drug | Observe the incidence of pruritus and paresthesia after different doses of remifentanil and fospropofol disodium |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of pruritus and paresthesia after administration of fospropofol disodium | Observe the incidence of pruritus and paresthesia in patients within 3 minutes after administration | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Time of pruritus or paresthesia | time of pruritus and paresthesia occur after administration and 24h after surgery | 1 day |
| dosage of drugs | Doses of drugs used during induction and maintenance of anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| aihua Du, Dr. | Tongji Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital | Wuhan | Hubei | 430030 | China |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| D017409 | Sufentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Sufentanil | Drug | Observe the incidence of pruritus and paresthesia after sufentanil and fospropofol disodium |
|
|
| 1 day |
| time records checklist | anesthesia time, induction time, surgical time, awakening time, and recovery time | 1 day |
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 | Incidence of Treatment-Emergent Adverse Events | 1 day |
| duration of pruritus or paresthesia | pruritus and paresthesia occur after administration and 24h after surgery | 24 hours |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005283 | Fentanyl |