The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients

To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients

The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients.

Inclusion Criteria:

• ≥ 65 years ASA class I-II who received surgery with endotracheal intubation

Exclusion Criteria:

• emergency surgery
• electrocardiography abnormality
• hypertension
• diabetes mellitus
• end stage renal disease
• moderate to severe cardiac disease
• moderate to severe liver dysfunction