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The investigator designed this study to investigate remifentanil effect-site concentration in 95% of patients (EC95) for preventing cough after laryngomicrosurgery from propofol anesthesia.
At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). Extubation was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remifentanil | Experimental | Extubation was performed when remifentanil was maintained a predetermined concentration throughout the emergence periods. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil | Drug | The concentration of remifentanil was determined by biased-coin up and down design, starting from 1.0 ng/ml (0.4 ng/ml as a step size) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of cough | Number of cough or a strong and sudden contraction of the abdomen during periextubation periods | from end of surgery to 5 min after tracheal extubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou University Hospital | Suwon | Gyeonggi-do | 443-721 | South Korea |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Propofol anesthesia | Drug | Anesthesia was induced with propofol target-controlled infusion at an effect-site concentration of 5.0 μg/ml. |
|
|
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |