Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy

In patients undergoing hypophysectomy through transsphenoidal approach, preventing cough during anesthetic emergence is important to avoid hemorrhage and cerebrospinal fluid leakage. Previous reports demonstrated that administration of remifentanil during anesthetic emergence could reduce the incidence and severity of cough during anesthetic emergence. Therefore, the objective of this study is to determine EC95 of remifentanil for preventing cough during anesthetic emergence in patients undergoing hypophysectomy with transsphenoidal approach.

Inclusion Criteria:

• scheduled to undergo hypophysectomy with transsphenoidal approach
• American Society of Anesthesiologists physical status I or II
• more than 20 years old

Exclusion Criteria:

• acute or chronic respiratory disease
• uncontrolled hypertension
• taking sedatives or anti-tussive
• gastro-esophageal reflux
• pregnant or breast feeding
• patients who cannot understand statements for subjects or this study itself