Botulinum Toxin A in the Treatment of Hemifacial Spasm

Does Bilateral Botulinum Toxin A in Patients With Hemifacial Spasm Improve Facial Symmetry Unilateral and Bilateral Injection of Botulinum Toxin A in Patients With Hemifacial Spasm? A Prospective, Randomized, Controlled Study

Hemifacial spasm patients who received botulinum toxin A injection were divided into two groups. Group A received unilateral injection while group B received bilateral injection. Patients completed follow-up A researcher record facial videos and analyzed facial symmetry and completed 3 scales.

Hemifacial spasm patients who received botulinum toxin A injection were divided into two groups.Patients of unilateral group were injected to the affected side and the dose of botulinum toxin A was 2.5-3.75 units/per site. Patients of bilateral group were injected to the affected side with dose of 2.5-3.75 units/per site and the normal side was injected with dose of 1.25 units/per site.

3 scales for measurement were used.

Inclusion Criteria:

• clinical diagnosis of hemifacial spasm
• Scott grading III to IV
• hemifacial spasm duration of half or more years
• last botulinum toxin A application at least 3 months before the start of the study

Exclusion Criteria:

• history of facial trauma, congenital facial asymmetry, facial nerve microsurgical decompression
• bilateral hemifacial spasm
• allergies to botulinum toxin A or to any component of the drug
• previous treatment with botulinum toxin A fewer than 3 months
• the use of drugs that could interfere with neuromuscular transmission or spasm