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The purpose of this study is to determine whether pretarsal and preseptal techniques of Botulinum toxin type A injection have any effect on tear functions.
Botulinum toxin type A has been used for hemifacial spasm since 1986. of Botulinum toxin type A can be subcutaneously injected at pretarsal or preseptal portion of orbicularis muscle. Blepharoptosis has been reported less frequently with pretarsal technique, however dry eye was noticed in one patient treated with pretarsal botulinum toxin type A for cosmetic purpose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| preseptal | Experimental |
| |
| pretarsal | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| preseptal injection of botulinum toxin type A | Drug | botulinum toxin type A (Botox)2.5 units, 5 points |
|
| Measure | Description | Time Frame |
|---|---|---|
| tear break up time | unit of measure; minutes | change from baseline in tear break up time at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| schirmer's test | units of measurement; millimeters | change from baseline of schirmer's test at 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| kitthisak kitthaweesin, ND | Contact | 6643348383 | kitthisak@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| kitthisak kithaweesin, MD | Khon Kaen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Khon Kaen University | Muang | Changwat Khon Kaen | 40002 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8501266 | Result | Price J, O'Day J. A comparative study of tear secretion in blepharospasm and hemifacial spasm patients treated with botulinum toxin. J Clin Neuroophthalmol. 1993 Mar;13(1):67-71. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 31, 2015 | |
| Reset | Jun 15, 2015 |
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| pretarsal injection of Botulinum toxin type A | Drug | Botulinum toxin type A 2,5 units, 5 points |
|
|
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 31, 2015 | Jun 15, 2015 |
| ID | Term |
|---|---|
| D019569 | Hemifacial Spasm |
| D022125 | Lacerations |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
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