Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm

Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm

The purpose of this study is to determine whether pretarsal and preseptal techniques of Botulinum toxin type A injection have any effect on tear functions.

Botulinum toxin type A has been used for hemifacial spasm since 1986. of Botulinum toxin type A can be subcutaneously injected at pretarsal or preseptal portion of orbicularis muscle. Blepharoptosis has been reported less frequently with pretarsal technique, however dry eye was noticed in one patient treated with pretarsal botulinum toxin type A for cosmetic purpose.

Inclusion Criteria:

• patient diagnosed with hemifacial spasm

Exclusion Criteria:

• previous history of botulinum toxin treatment for hemifacial spasm
• ocular surface disorders
• tear disorders
• evidence of infection at or around eyelids
• pregnant woman
• other neurologic disease, i.e. OMG
• coagulopathy or treatment with thrombolytic agent
• treatment with aminoglycosides, chloroquine, hydroxychloroquine