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Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Imaging healthy volunteers | Experimental | Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mood induction (using own memories) | Behavioral | Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI |
| Measure | Description | Time Frame |
|---|---|---|
| Regional Cerebral perfusion (ml/100g/min) during positive mood induction | Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) |
| Regional Cerebral perfusion (ml/100g/min) during negative mood induction | Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) |
| Regional Cerebral perfusion (ml/100g/min) during neutral mood induction | Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan during mood state induction) |
| Regional Cerebral perfusion (ml/100g/min) after positive mood induction | Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) |
| Regional Cerebral perfusion (ml/100g/min) after negative mood induction | Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) |
| Regional Cerebral perfusion (ml/100g/min) after neutral mood induction | Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI. | 2 minutes (ASL scan after mood state induction) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Achten, MD, PhD | University Hospital, Ghent | Principal Investigator |
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| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Arterial spin labeling MRI | Device | Single PLD PCASL |
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| Physiological monitoring | Device | During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance |
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