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Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Natural cycle | 15 female volunteers, not using hormonal contraception, will be scanned during 3 menstrual cycles. During each cycle, the volunteers will be scanned 3 times: during the follicular phase, during ovulation and during luteal phase. |
| |
| Anti-conception | 15 female volunteers, using hormonal contraception pill Deso 20, will be scanned during 3 menstrual cycles. During each cycle, the volunteers will be scanned 2 times: during the pill-week and during the pill-free week. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI scan | Device | Several MRI scan modalities: MPRAGE (structural scan), arterial spin labeling (cerebral perfusion), resting state functional-MRI (fMRI, cerebral activity) and diffusion MRI (white matter diffusion and white matter tracts). |
| Measure | Description | Time Frame |
|---|---|---|
| Regional cerebral perfusion (ml/100g/min): natural versus contraception | Differences in regional perfusion between volunteers of the natural cycle group versus the volunteers using contraception | measured during scan-session |
| Regional cerebral perfusion (ml/100g/min) variations during natural menstrual cycle | Variations in cerebral perfusion during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample | measured during scan-session |
| Regional cerebral perfusion (ml/100g/min) variations during menstrual cycle using contraception | Variations in cerebral perfusion during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample | measured during scan-session |
| Measure | Description | Time Frame |
|---|---|---|
| Regional grey matter volume (mm³): natural versus contraception | Differences in regional grey matter volume between volunteers of the natural cycle group versus the volunteers using contraception | measured during scan-session |
| Regional grey matter volume (mm³) variations during natural menstrual cycle |
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Inclusion Criteria:
Exclusion Criteria:
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30 healthy young volunteers, either using no hormonal anti-conception, either using Deso20 as anti-conception.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patricia Clement, Msc | Contact | 9 332 1330 | +32 | patricia.clement@ugent.be |
| Name | Affiliation | Role |
|---|---|---|
| Eric Achten, MD, PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University Hospital | Recruiting | Ghent | 9000 | Belgium |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| D008991 | Monitoring, Physiologic |
| D001800 | Blood Specimen Collection |
| D001795 | Blood Pressure Determination |
| D001831 | Body Temperature |
| D011795 | Surveys and Questionnaires |
| D011258 | Pregnancy Tests |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Physiological monitoring | Device | During MRI: heart rate, end-tidal carbon dioxide (CO2), respiratory rate and skin conductance |
|
| Blood sample | Biological | Blood sample after MRI-session: measurement of hematocrit, hemoglobin, estradiol, progesterone, follicle stimulation hormone and luteinizing hormone. |
|
| Blood pressure measurement | Device | Measuring blood pressure before and after MRI-scan |
|
| Body temperature | Device | Measuring body temperature before and after MRI-scan |
|
| Questionnaires | Other | Questionnaires at the start of the study on lifestyle. Additionally, a questionnaire before each scan session on the actual state of the volunteer (e.g. mood, caffeine consumption, alcohol, medication, etc.) |
|
| Pregnancy test | Diagnostic Test | Test for pregnancy using a pregnancy dipstick test |
|
Variations during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample |
| measured during scan-session |
| Regional grey matter volume (mm³) variations during menstrual cycle using contraception | Variations in grey matter volume during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample | measured during scan-session |
| Resting state brain activity: natural versus contraception | Differences in resting state brain activity between volunteers of the natural cycle group versus the volunteers using contraception | measured during scan-session |
| Resting state brain activity variations during natural menstrual cycle | Variations in resting state brain activity during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample | measured during scan-session |
| Resting state brain activity variations during menstrual cycle using contraception | Variations in resting state brain activity during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample | measured during scan-session |
| Cerebral diffusion properties: natural versus contraception | Differences in diffusion properties (Mean Diffusivity(MD)/Apparent Diffusion Coefficient (ADC)/fractional Anisotropy(FA)) between volunteers of the natural cycle group versus the volunteers using contraception | measured during scan-session |
| Cerebral diffusion properties variations during natural menstrual cycle | Variations in diffusion properties (MD/ADC/FA) during the menstrual cycle: follicular phase versus ovulation versus luteal phase in the natural cycle group, correlated with female hormones measured in blood sample | measured during scan-session |
| Cerebral diffusion properties variations during menstrual cycle using contraception | Variations in diffusion properties (MD/ADC/FA) during the menstrual cycle: pill-week versus pill-free week in the contraception group, correlated with female hormones measured in blood sample | measured during scan-session |
| D013048 |
| Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D010808 | Physical Examination |
| D055986 | Vital Signs |
| D010829 | Physiological Phenomena |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D003944 | Diagnostic Techniques, Obstetrical and Gynecological |