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| Name | Class |
|---|---|
| Khalifa University for Science and Technology | OTHER |
| New York University Abu Dhabi | OTHER |
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The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.
The investigators seeks to fill a significant gap in our understanding of the impact of ovarian stimulation on brain dynamics, an area that has not been previously explored. By investigating the brain's dynamic complexity across controlled ovarian stimulation cycle the investigators aim to shed light on how externally administered hormones influence brain activity patterns. Utilizing resting-state Functional Magnetic Resonance Imaging to examine a sample of young, healthy, naturally cycling women, this research will provide crucial insights into the safety and neurophysiological effects of ovarian stimulation. Understanding these effects is essential for ensuring the well-being of women undergoing oocyte freezing and other fertility treatments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young (age range 25-35), healthy , who want to undergo ovarian stimulation for oocyte vitrification. | - Initial Assessment of Volunteers for Inclusion in the study. Once included, volunteers will need to be assessed 8 times during the study period, with 6 fMRI scans:
Every stage will include a blood test for hormonal evaluation, vaginal ultrasound for follicular count & sizing, administration of MRI protocol. The first visit will include buccal swab. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval. | Diagnostic Test | Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval. |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity using functional magnetic resonance imaging (fMRI). | Comparison of brain activity between the natural menstrual cycle and a stimulated cycles using functional magnetic resonance imaging (fMRI) at three cycle points. | Measure at three cycle points: basal (day 2-3), ovulation (during ovulation or day after trigger-shot), and at luteal phase (7-10 days after ovulation or trigger shot). |
| Measure | Description | Time Frame |
|---|---|---|
| Hormonal levels (Estradiol, LH, FSH, Progesterone) fluctuation. | Analyze relation of hormonal fluctuations (Estradiol, LH, FSH, Progesterone) at three cycle points with brain dynamics and neural connectivity. | Measure at three cycle points: basal (day 2-3), ovulation (during ovulation or day after trigger-shot), and at luteal phase (7-10 days after ovulation or trigger shot). |
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Inclusion Criteria:
Exclusion Criteria:
Only naturally cycling women.
Young (age range 25-35), healthy, naturally cycling women with a normal BMI, who want to undergo ovarian stimulation for oocyte vitrification.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Raquel Del Gallego, PhD | Contact | +971 2 6528000 | raquel.delgallego@artfertilityclinics.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ART Fertility Clinics LLC | Recruiting | Abu Dhabi | Abu Dhabi Emirate | 00000 | United Arab Emirates |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33688609 | Background | Mueller JM, Pritschet L, Santander T, Taylor CM, Grafton ST, Jacobs EG, Carlson JM. Dynamic community detection reveals transient reorganization of functional brain networks across a female menstrual cycle. Netw Neurosci. 2021 Feb 1;5(1):125-144. doi: 10.1162/netn_a_00169. eCollection 2021. | |
| 32621974 | Background |
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The first visit will include an additional genetic testing, to perform association analysis between genetic and neuroimaging and fertility data. The investigator will collect saliva samples from the study participants during their visit to NYUAD using a standard saliva collection kit. Samples will be stored on the facility freezers.
| Whole genome sequencing of patient. | Sequence patient's genome using saliva sampling to observes the genetic basis of fertility traits, to identify genetic variants associated with various neural and fertility phenotypes. | Day 1 - baseline saliva sample collection. |
| ART Fertility Clinics LLC | Recruiting | Abu Dhabi | Abu Dhabi Emirate | 60202 | United Arab Emirates |
|
| Pritschet L, Santander T, Taylor CM, Layher E, Yu S, Miller MB, Grafton ST, Jacobs EG. Functional reorganization of brain networks across the human menstrual cycle. Neuroimage. 2020 Oct 15;220:117091. doi: 10.1016/j.neuroimage.2020.117091. Epub 2020 Jul 2. |