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The main aim of the study is to examine whether the effects of intranasal oxytocin on eye-gaze behavior towards social stimuli are modulated via individual differences in trait autism
In this double-blind, within subject, placebo controlled design a total of n = 40 healthy male subjects will receive either 24 IU of oxytocin or placebo (interval between administration > two weeks). 45 minutes after treatment subjects will undergo a total of 7 eye-tracking paradigms examining eye-gaze behavior during social processing: (1) dynamic social-nonsocial visual preference task during which movies of dynamic geometric images (DGI) and dynamic social images (DSI) will be presented; (2) non-biological versus biological motion task; (3) social attention and motivation of sharing enjoyment; (4) preference for emotional faces versus schematic faces (emoticons); (5) shared social attention - shared gaze direction with an actor shifting his attention to different objects; (6) preferred visual scanning of face regions in emotional faces; and, (7) eye gaze in response to empathy eliciting visual stimuli. Autistic and associated traits will be assessed using the Autism Spectrum Quotient (ASQ), Social Responsibilities Scale (SRS) and the Interpersonal Reactivity Index (IRI). Within-subject differences in the effects of oxytocin on social eye gazing behaviour will be related to individual differences in autistic traits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Order of administration: oxytocin - placebo | Experimental | Participants first receive oxytocin (24 IU). After a washout period of 2 weeks, they receive placebo nasal spray |
|
| Order of administration: placebo - oxytocin | Experimental | Participants first received placebo nasal spray. After a washout period of 2 weeks, they then receive oxytocin (24 IU). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intranasal oxytocin | Drug | 24 IU of oxytocin nasal spray will be applied to each subject. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Global eye gaze characteristic: differences between oxytocin and placebo treatment | Global eye-gaze patterns will be compared between the administration of oxytocin and placebo | 45-90 minutes after treatment administration |
| Feature-specific eye gaze characteristics: differences between oxytocin and placebo treatment | Localized feature-specific eye gaze patterns will be compared between oxytocin and placebo treatment | 45-90 minutes after treatment administration |
| Measure | Description | Time Frame |
|---|---|---|
| Global eye gaze characteristic - associations with autism traits | Within-subject differences in global eye gaze characteristics between the oxytocin and placebo administration will be examined for associations with individual differences in autism traits | 45-90 minutes after treatment administration |
| Feature-specific eye gaze characteristics - associations with trait autism |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Keith M Kendrick, PhD | Contact | 86-28-61830811 | k.kendrick.uestc@gmail.com | |
| Benjamin Becker, PhD | Contact | 86-28-61830988 | ben_becker@gmx.de |
| Name | Affiliation | Role |
|---|---|---|
| Juan Kou, MSc | University of Electronic Science and Technology of China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| school of life science and technology, University of Electronic Science and Technology of China | Recruiting | Chengdu | Sichuan | 610054 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32848571 | Derived | Le J, Kou J, Zhao W, Fu M, Zhang Y, Becker B, Kendrick KM. Oxytocin Facilitation of Emotional Empathy Is Associated With Increased Eye Gaze Toward the Faces of Individuals in Emotional Contexts. Front Neurosci. 2020 Aug 11;14:803. doi: 10.3389/fnins.2020.00803. eCollection 2020. |
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Randomized placebo-controlled double-blind within-subject design
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| intranasal placebo | Drug | 24 IU of of placebo nasal spray will be applied to each subject. |
|
Within-subject differences in localized feature-specific eye gaze characteristics between the oxytocin and placebo administration will be examined for associations with individual differences in autism traits |
| 45-90 minutes after treatment administration |
| University of Electronic Science and Technology of China | Recruiting | Chengdu | Sichuan | 611731 | China |