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The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival thickness without the need for surgical procedures
Due to the thin gingival phenotype, gingival recession is a problem. The investigators aimed to increase the gingival thickness using i-PRF with microneedle without considering surgical procedures, considering the positive effects of platelet concentrations on revascularization and wound healing in individuals with bone defect, fenestration and gingival thickness which are prone to gingival recession .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I-PRF | Experimental | Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Apply once a week and one month after the end of the injections, the patient will be called to the control. |
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| I-PRF and Microneedling | Active Comparator | Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| I-PRF | Other | Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control. |
| Measure | Description | Time Frame |
|---|---|---|
| Gingival thickness (mm) | Change in clinical measures of gingival thickness | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index (PI) | Change in clinical measures of gingival parameters | 2 months |
| Gingival Index (GI) | Change in clinical measures of gingival parameters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zeliha Betül Özsağır | Bezmialem VU | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zeliha Betül ÖZSAĞIR | Istanbul | 34093 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31912532 | Derived | Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. J Clin Periodontol. 2020 Apr;47(4):489-499. doi: 10.1111/jcpe.13247. Epub 2020 Feb 11. |
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D004194 | Disease |
| D013927 | Thrombosis |
| D005882 | Gingival Diseases |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| C043309 | proliferation regulatory factors, human urine |
| D000097244 | Percutaneous Collagen Induction |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D011677 | Punctures |
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Blinded, Parallel group, Randomized Controlled Trial
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|
| 2 months |
| Bleeding on probing (BOP) | Change in clinical measures of gingival parameters | 2 months |
| Clinical attachment level (CAL) | Change in clinical measures of gingival parameters | 2 months |
| Probing pocket depth (PD) | Change in clinical measures of gingival parameters | 2 months |
| D002318 | Cardiovascular Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D012046 |
| Rehabilitation |