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This clinical trial aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) and concentrated platelet-rich fibrin (C-PRF) on gingival phenotype in patients undergoing mucogingival surgery with the VISTA technique. Changes in gingival thickness and width of keratinized gingiva will be assessed using both manual and digital methods.
The study is designed as a randomized controlled clinical trial including 30 patients, divided into two groups: I-PRF and C-PRF. All participants receive a mucogingival procedure using the VISTA technique followed by four sessions of PRF injections (one during surgery and three at 10-day intervals). The primary outcomes are changes in gingival thickness and the width of keratinized gingiva, measured manually and digitally at baseline, 1 month, 3 months and 6 months. The aim is to compare the effectiveness of I-PRF and C-PRF on soft tissue enhancement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| C-PRF Group | Experimental | Concentrated platelet-rich fibrin was prepared using horizontal centrifugation and injected at 4 time points (once during the VISTA procedure, and 3 additional times at 10-day intervals). |
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| I-PRF Group | Experimental | Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Concentrated PRF | Biological | Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in gingival thickness | Gingival thickness will be measured manually (using a spreader) to assess the effect of I-PRF and C-PRF over time. | Baseline, 1 month, 3 months and 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in width of keratinized gingiva | The width of keratinized gingiva will be measured manually using a periodontal probe to evaluate the soft tissue augmentation potential of C-PRF and I-PRF. | Baseline, 1 month, 3 months and 6 months |
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Inclusion Criteria:
Systemically healthy individuals (ASA I) Age between 18 and 45 years Non-smokers Gingival thickness ≤ 0.8 mm in the mandibular anterior region No restorations, missing teeth, or supernumerary teeth in the mandibular anterior region Full-mouth plaque index (PI) < 15% Full-mouth bleeding on probing (BOP) < 15%
Exclusion Criteria:
Presence of systemic disease or coagulation disorders Use of antibiotics or anti-inflammatory drugs within the last 3 months Smoking History of bruxism Pregnancy or lactation Ongoing orthodontic treatment Use of medications affecting gingival phenotype (e.g., calcium channel blockers, anticonvulsants) Presence of infection, lesion, or trauma at the surgical site History of periodontal surgery in the relevant area
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inonu University Faculty of Dentistry | Malatya | Turkey (Türkiye) |
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Two-arm parallel design comparing the effects of I-PRF and C-PRF on gingival phenotype using VISTA technique.
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| Injectable PRF | Biological | Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals). |
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