Effect of L-PRF and A-PRF in Ridge Preservation

The Use of L-PRF and A-PRF in Ridge Preservation: a Randomized Controlled Clinical Trial

A split-mouth design study will be performed regarding the use of platelet concentrates on ridge preservation: L-PRF vs A-PRF vs control. Patient needing multiple teeth extractions in the upper jaw (single-rooted teeth) will be recruited. The use of each platelet concentrate or control will be randomized by means of a computer program. The results will be analysed clinical and radiographically (CBCT). When the subject will choose for implant rehabilitation, a biopsy will be taken in the site of the preserved sockets. The region will be localized with a customized stent, fabricated with the position of the extracted teeth. VAS scales will be provided to evaluate the post-operative discomfort.

Inclusion Criteria:

• 3 single-rooted teeth needed to be extracted in the upper jaw
• patient in good general health as documented by self-assessment
• patients must be committed to the study and must be willing to sing the informed consent.

Exclusion Criteria:

• any systemic medical condition that could interfere with the surgical procedure or planned treatment.
• current pregnancy or breast feeding
• radiotherapy or chemotherapy in head and neck area
• intravenous and oral bisphosphonate
• patients smoking >20 cig/day
• unwillingness to return for the follow-up examination