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The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-PRF group | Experimental | The use of autologous leucocyte- and platelet-rich fibrin in alveolar sockets after dental extraction. |
|
| Control | No Intervention | Conventional tooth extraction without any bone substitute. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet-rich fibrin | Procedure | The use of autologous platelet-rich fibrin after tooth extraction to promote bone healing and alveolar ridge preservation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Width resorption 1mm | The ridge width differences between baseline and after three months of healing 1 mm below the crest. | After 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Width resorption 3mm | The ridge width differences between baseline and after three months of healing 3 mm below the crest. | After 3 months |
| Width resorption 5mm | The ridge width differences between baseline and after three months of healing 5 mm below the crest. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| João Canellas, MSc | Rio de Janeiro State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rio de Janeiro State University | Rio de Janeiro | 20551-030 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31810848 | Derived | Canellas JVDS, da Costa RC, Breves RC, de Oliveira GP, Figueredo CMDS, Fischer RG, Thole AA, Medeiros PJD, Ritto FG. Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial. J Craniomaxillofac Surg. 2020 Jan;48(1):24-32. doi: 10.1016/j.jcms.2019.11.006. Epub 2019 Nov 29. |
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
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|
| After 3 months |
| Histological Analysis - fibrous tissue | The percentage of soft (fibrous) tissue | After 3 months |
| Histological Analysis - bone cells | Quantity of bone cells (osteoblast, osteoclast and osteocyte) | After 3 months |
| Histological Analysis - capillary vessels | Quantity of capillary vessels | After 3 months |
| Histological Analysis - new bone formation | The percentage of the newly formed bone | After 3 months |
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |